Prognostic Significance of the Microvessel Density in Nasopharyngeal Carcinoma.
- Author:
Sang Chul LIM
1
;
Jae Shik CHO
;
Ae Sun NA
;
Pan Su KIM
;
Hyong Ho CHO
;
Seok Jin MOON
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, Chonnam University Medical School, Gwangju, Korea. cjscyy@chonnam.ac.kr
- Publication Type:Original Article
- Keywords:
Nasopharyngeal neoplasms;
Von Willebrand factor;
Prognosis
- MeSH:
Jeollanam-do;
Microvessels*;
Nasopharyngeal Neoplasms;
Paraffin;
Prognosis;
Radiotherapy;
Rare Diseases;
Survival Rate;
von Willebrand Factor
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2002;45(10):980-983
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: The nasopharyngeal cancer (NPC) of nasopharyngeal neoplasms is a rare disease with a relatively poor prognosis, because they tend to be diagnosed in the far advanced stage. Therefore, radiotherapy had been the treatment of choice. Angiogenesis is a crucial step in the tumor growth and progression. The authors attempted to investigate the prognostic value of the microvessel density in NPC. SUBJECTS AND METHOD: We analyzed tumor tissues from 57 cases of paraffin block specimens which had been diagnosed with NPC and treated at Chonnam National University Hospital. The anti-human von Willebrand factor antibody was used to determine the microvessel density (MVD). RESULTS: The MVD was 48.5 in the early stage (stage I and II) and 51.2 in the advanced stage (stage III and IV), which were not statistically significant (p=0.057). The MVD was 55.3 in type I, 54.4 in type II, and 41.8 in type III, and there were no statistical significance between these values (p=0.36). The MVD was not statistically significant between T and N stages (p=0.26, 0.42). There was no significance between the MVD and the survival rates (p>0.05). CONCLUSION: The results suggest that the MVD was not a prognostic significance in NPC.
