Optimal Continuous Positive Airway Pressure Level in Korean Patients with Obstructive Sleep Apnea Syndrome.
- Author:
Ji Ho CHOI
1
;
Eun Joong KIM
;
Kang Woo KIM
;
June CHOI
;
Soon Young KWON
;
Heung Man LEE
;
Tae Hoon KIM
;
Sang Hag LEE
;
Chol SHIN
;
Seung Hoon LEE
Author Information
- Publication Type:Original Article
- Keywords: Obstructive sleep apnea syndrome; Continuous positive airway pressure; Polysomnography; Body mass index
- MeSH: Arousal; Body Mass Index; Continuous Positive Airway Pressure; Humans; Linear Models; Neck; Polysomnography; Sleep Apnea, Obstructive
- From:Clinical and Experimental Otorhinolaryngology 2010;3(4):207-211
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVES: The aim of this study was to investigate optimal continuous positive airway pressure (CPAP) level, to examine the factors affecting optimal CPAP level, and to develop a predictive equation for optimal CPAP level in Korean patients with obstructive sleep apnea syndrome (OSAS). METHODS: A total of 202 patients with OSAS who underwent successful manual titration for CPAP treatment were included in this study. Correlations between the optimal CPAP level and baseline data including anthropometric and polysomnographic variables were analyzed. A predictive equation for optimal CPAP level was developed based on anthropometric and polysomonographic data. RESULTS: The mean optimal CPAP level in 202 patients with OSAS was 7.8+/-2.3 cm H2O. The mean optimal CPAP level in the mild, moderate, and severe OSAS groups was 6.0+/-1.3, 7.4+/-1.9, and 9.1+/-2.1 cm H2O, respectively. The apneahypopnea index (AHI) (r=0.595, P<0.001), arousal index (r=0.542, P<0.001), minimal SaO2 (r=-0.502, P<0.001), body mass index (BMI) (r=0.494, P<0.001), neck circumference (r=0.265, P<0.001), and age (r=-0.164, P=0.019) were significantly correlated with optimal CPAP level. The best predictive equation according to stepwise multiple linear regression analysis was: Optimal CPAP level (cm H2O)=0.681+(0.205xBMI)+(0.040xAHI). Forty-two percent of the variance in the optimal CPAP level was explained by this equation (R2=0.42, P<0.001). CONCLUSION: A predictive equation for optimal CPAP level in Korean patients with OSAS was developed using AHI and BMI, which can be easily measured during the diagnostic process.
