Effect of Chronical Ethanol Ingestion on the Levels of Fatty Acid Ethyl Esters (FAEEs) and Lipid Peroxidation in Rat Tissues.
- Author:
Min Seok KIM
1
;
Se Na KIM
;
Hyun Suh PARK
Author Information
1. Department of Food and Nutrition, Kyung-Hee University, Seoul 130-701, Korea. hspark@khu.ac.kr
- Publication Type:Original Article
- Keywords:
chronical ethanol ingestion;
non-oxidative metabolism;
fatty acid ethyl esters;
oxidative stress
- MeSH:
alpha-Tocopherol;
Animals;
Brain;
Control Groups;
Diet;
Eating*;
Esters*;
Ethanol*;
Humans;
Lipid Peroxidation*;
Liver;
Male;
Maltose;
Metabolism;
Oxidative Stress;
Pancreas;
Rats*;
Rats, Sprague-Dawley;
Thiobarbituric Acid Reactive Substances
- From:The Korean Journal of Nutrition
2007;40(5):413-418
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The present study was designed to observe the effect of chronically ingested ethanol on the level of fatty acid ethyl esters (FAEEs), which is a non-oxidative metabolite of ethanol metabolism in tissues, and its correlation to the status of oxidative stress in rats. Forty male Sprague Dawley rats weighing 145 - 155 g were divided into 2 groups, Control and EtOH. All rats were fed Lieber-DeCarli liquid diet for 4 weeks by pair-feeding. An isocaloric maltose dextrin was added in replace of 50 g ethanol (36%kcal) in the control diet. Chronically ingested ethanol significantly increased the content of FAEEs in pancreas and liver, but not in brain. The level of 2-thiobarbituric acid reactive substances (TBARS) was significantly increased, but alpha-tocopherol level was significantly decreased in pancreas and liver. However, the levels of TBARS and alpha-tocopherol in brain were not significantly affected by ethanol ingestion. Therefore, chronically ingested ethanol might cause tissue damage by increasing the levels of FAEEs and TBARS and dissipating more alpha-tocopherol in tissues.
