Expression of CD44s, v3 and v6 in Squamous Cell Carcinoma of the Head and Neck.
- Author:
Sang Hyun KIM
1
;
Jun Hwan MOON
;
Ho Sang NO
;
Seong Wook MOON
;
Chel SHIN
;
Hee Jin CHANG
;
Hyoung Rae SON
;
Hye Jin CHOI
Author Information
1. Department of Otolaryngology, National Medical Center, Seoul, Korea. nmcent2@netsgo.com
- Publication Type:Original Article
- Keywords:
CD44 variant;
Head and neck neoplasms;
Biologic markers
- MeSH:
Alternative Splicing;
Biomarkers;
Carcinoma, Squamous Cell*;
Cell Adhesion;
Cell Membrane;
Exons;
Glycoproteins;
Head and Neck Neoplasms;
Head*;
Humans;
Hyaluronic Acid;
Lymph Nodes;
Neck*;
Neoplasm Metastasis;
Paraffin;
Prognosis;
Protein Isoforms
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2001;44(9):951-956
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: CD44 is a transmembrane glycoprotein that mediates cell adhesion through binding to extracelluar matrix molecules such as hyaluronan. Multiple isoforms of CD44 are generated by alternative splicing of 10 separate exons (v1-v10). Some of them have been noted as markers for tumor metastasis and prognosis in several studies. We investigated whether CD44s, v3 and v6 may be a useful markers in the head and neck squamous cell carcinoma. MATERIALS AND METHOD: Paraffin embedded tissue sections, which was diagnosed as squamous cell carcinoma of the head and neck from 41 patients were stained immunohistochemically with monoclonal Ab of CD44s, v3 and v6. The results were compared with the primary tumor status, lymph node metastasis, histopathologic differentiation and survival. RESULTS: Various levels of immunoreactivities of the CD44s, CD44v3 and CD44v6 were detected dominantly in cancer cell membrane. The positive rate of CD44s, CD44v3 and CD44v6 were 59%, 66%, 71%, respectively. The decreased expression of CD44s and CD44v6 was significantly correlated to lymph node metastasis but was not affected by T-stage, histopathologic differentiation and survival. CD44v3 had no correlation with the T-stage, N-stage, pathologic differentiation nor survival. CONCLUSION: The expression of CD44s and CD44v6 in the head and neck squamous cell carcinoma may be a biologic marker for lymph node metastasis.
