Immunoglobulin E and Transcription Factor in Adenoid of Children with Allergy.
10.3342/kjorl-hns.2009.52.7.594
- Author:
Young Gyu EUN
1
;
Seung Geun YEO
;
Hoon CHUNG
;
Dae Han CHUNG
;
Myung Gu KIM
;
Jae Yong BYUN
;
Moon Suh PARK
;
Chang Il CHA
Author Information
1. Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Sungkyunkwan University, Masan Samsung Hospital, Masan, Korea.
- Publication Type:Original Article
- Keywords:
Adenoid;
IgE;
BCL-6;
Blimp-1;
Allergy
- MeSH:
Adenoids;
Child;
Germinal Center;
Humans;
Hypersensitivity;
Immunoglobulin E;
Immunoglobulins;
Lymphocytes;
Mucous Membrane;
Rhinitis;
Rhinitis, Allergic, Perennial;
Transcription Factors
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2009;52(7):594-598
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Immunoglobulin E (IgE) production in adenoid has been debated and the role of adenoid in development of allergy remains largely unknown. To examine the production of local IgE in adenoid involved with IgE-mediated sensitization, we evaluated IgE production and the expression of the transcription factor B cell leukemia/lymphoma-6 (BCL-6) and B lymphocyte inducer of maturation program 1 (Blimp-1) in adenoids. SUBJECTS AND METHOD: Ten children with allergic rhinitis (AR) and ten children without any history of AR were enrolled. Immunohistochemical studies of adenoid for IgE, BCL-6 and Blimp-1 were performed. RESULTS: IgE was stained mainly in the germinal center and submucosal area and the stainingscores of antibody to IgE did not differ signigicantly between children with AR and control. BCL- 6 was mainly stained in mucosa and germinal center and Blimp-1 in mucosa. The scores of antibody to BCL-6 and Blimp-1 in children with AR and control did not show significant differences. CONCLUSION: We found that allergic rhinitis was not involved in the production of IgE nor the expression of the transcription factor BCL-6 and Blimp-1 in adenoid
