Nociceptive and Trigeminal Cardiovascular Reflex Mechanisms after Noxious Intrapulpal Stimulation of the Rat Incisors.
- Author:
Ji Yeon JUNG
1
;
Yeon Jin JEONG
;
Sun Hun KIM
;
Won Mann OH
;
Ki Heon LEE
;
Min Seok KIM
;
Ok Joon KIM
;
Ha Ok PARK
;
Hee Kyun OH
;
Eun Ju LEE
;
Mi Won KIM
;
Won Jae KIM
Author Information
1. Dental Science Research Institute, College of Dentistry, Chonnam National University, Korea. wjkim@chonnam.ac.kr
- Publication Type:Original Article
- Keywords:
c-Fos;
Noxious intrapulpal stimulation;
Immunocytochemistry
- MeSH:
Animals;
Arterial Pressure;
Blood Pressure;
Brain;
Heart Rate;
Hypothalamus;
Immunohistochemistry;
Incisor*;
Medulla Oblongata;
Neurons;
Paraventricular Hypothalamic Nucleus;
Rats*;
Rats, Sprague-Dawley;
Reflex*;
Solitary Nucleus;
Supraoptic Nucleus;
Thalamus;
Trigeminal Nuclei
- From:Korean Journal of Anatomy
2003;36(1):23-30
- CountryRepublic of Korea
- Language:English
-
Abstract:
Expression of c-Fos, an immediate early gene, has accepted to be a marker of functional activity in neurons. This study was aimed to investigate the dental pain pathway and the affection of dental pain on other brain regions such as the cardiovascular regulation center using c-Fos immunohistochemistry. Expression of c-Fos in Sprague Dawley rats weighting 300 ~350 gm was examined 1.5 hr after dental pain elicited by intrapulpal injecton of 2 M KCl into upper and lower incisor pulps exposed by bone cutter. c-Fos positive neurons were demonstrated in the trigeminal nucleus caudalis and the ventroposterior medial nucleus of thalamus known to be a sharp pathway. Dental pain enhanced mean arterial pressure and heart rate. In addition, c-Fos expression was induced in the rostral ventrolateral nucleus of medulla oblongata, nucleus tractus solitarius, paraventricular nucleus and supraoptic nucleus of hypothalamus, central presser areas of systemic blood pressure. These results suggest that trigeminal nucleus caudalis and ventroposterior medial nucleus of thalamus plays vital roles in the transmission of dental pain besides, dental pain affected the central cardiovescular regulation centers, resulting to the elevation of systemic blood pressure.
