Long Term Survival of Synovial Sarcoma and Treatment Strategy.
10.4055/jkoa.2004.39.3.329
- Author:
Won Seok SONG
1
;
Dae Geun JEON
;
Jong Hoon PARK
;
Wan Hyeong CHO
;
Soo Yong LEE
;
Jung Moon OH
;
Jin Wook KIM
Author Information
1. Department of Orthopedic Surgery, Korea Cancer Center Hospital, Seoul, Korea. SYLee@kcch.re.kr
- Publication Type:Original Article
- Keywords:
Synovial sarcoma;
Disease specific survival rate;
Treatment strategy
- MeSH:
Drug Therapy;
Humans;
Multivariate Analysis;
Neoplasm Metastasis;
Prognosis;
Recurrence;
Sarcoma, Synovial*
- From:The Journal of the Korean Orthopaedic Association
2004;39(3):329-334
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The object of the current study was to evaluate the long term survival of synovial sarcoma and to find an appropriate treatment strategy with a favorable prognosis. MATERIALS AND METHODS: Between August 1985 and June 2000, fifty nine synovial sarcoma patients without metastasis at presentation were analyzed and followed for 50.9 (8-161) months. Kaplan-Meier plots were used for survival analysis. Analyzed prognostic factors were sex, age, stage, location, surgical margin, chemotherapy, radiation therapy, local recurrence and metastasis. The log-rank test was used for univariate analysis and the Cox regression model for multivariate analysis. RESULTS: Fourteen-year actual and continuous disease free survivals (ADF/CDF) were 56.4 and 49.7%, respectively. CDF of stage I-IIa and IIb-III were 53.6 and 43.2%, respectively (p=0.55). For local recurrence according to surgical margin, 4 recurrences occurred in 44 wide margins, 1 recurrence in 6 marginal margins, and 1 recurrence in 2 intralesional margins. Among 10 cases of local recurrence, 4 cases had metastasis. Local recurrence, metastasis, and surgical margin had statistical significance in the univariate (p< 0.0001, p<0.0001, p=0.011) and multivariate analysis. CONCLUSION: Fourteen year CDF survival was 49.7%. The alleviation of local recurrence and metastasis is essential for long term survival. In the current study, the only factor under our control was surgical margin. A well designed surgical approach will reduce the recurrence rate.
