Analysis of c-Kit Gene Polymorphism in NK/T Cell Lymphoma in Korean Population.
- Author:
Hyung Jin KIM
1
;
Seung Kuk BAEK
;
Kwang Yoon JUNG
;
Seung Hoon LEE
;
Soon Yung KWON
;
Han Young CHOI
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea. entkwon@chollian.net
- Publication Type:Original Article
- Keywords:
T cell lymphoma;
Natural killer cell;
Proto-oncogene protein c-kit
- MeSH:
China;
Growth and Development;
Head;
Humans;
Interstitial Cells of Cajal;
Japan;
Killer Cells, Natural;
Lymphoma*;
Lymphoma, T-Cell;
Mast Cells;
Melanocytes;
Nasal Cavity;
Nasopharynx;
Neck;
Palate, Hard;
Palatine Tonsil;
Protein-Tyrosine Kinases;
Proto-Oncogene Proteins c-kit;
Proto-Oncogenes;
Stem Cell Factor;
Stem Cells
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2005;48(5):641-645
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: The proto-oncogene c-KIT encodes a receptor tyrosine kinase (KIT) whose ligand is a stem cell factor. KIT is expressed and critical for the development and growth of mast cells, melanocytes, hematopoetic stem cells, and the interstitial cells of Cajal. In this study, c-kit gene mutations were analyzed in 27 cases of NK/T cell lymphoma. SUBJECTS AND METHODS: During 1995 to 2002, 27 patients with NK/T cell lymphoma in the head and neck area were selected for this study. The nasal cavity were predominant sites (15 cases), followed by 6 nasopharynx cases, 4 tonsil 4 cases, and 2 hard palate cases. Gene mutation was analyzed by PCR-SSCP and direct sequencing. RESULTS: c-kit gene mutation was found in 5 of 27 cases by the PCR-SSCP method. Among the 5 cases, 2 cases exhibited no mutation by direct sequencing. Consequently, the mutation of c-kit gene was detected in 3 of 27 cases. CONCLUSION: The frequency of c-kit gene mutation (11%) indicated in the present cases is lower than that reported in north China but higher than that in Japan.
