Epidemiology and Clinical Characteristics of Childhood Acute Lymphoblastic Leukemia in Korea.

Kwang Chul Lee; Im Joo Kang; Shin Heh Kang; Hong Hoe Koo; Hoon Kook; Kir Young Kim; Moon Kyu Kim; Soon Kyum Kim; Hack Ki Kim; Hwang Min Kim; Heung Sik Kim; Seung Kon Nam; Hyung Nam Moon; Kyung Duk Park; Sae Myung Park; Jae Sun Park; Jong Young Park; Hyun Jin Park; Won Suk Suh; Jong Jin Seo; Ki Woong Sung; Sang Man Shin; Hee Young Shin; Tae Sub Shim; Don Hee Ahn; Hyo Seop Ahn; Chang Hyun Yang; Eun Suk Yang; Chan Wook Woo; Kyung Ha Ryu; Eun Sun Yoo; Chuhl Joo Lyu; Kun Soo Lee; Soon Yong Lee; Young Ho Lee; Hahng Lee; Young Tak Lim; Ho Joon IM; Bin Cho; Hyun Sang Cho; Kyu Chul Choeh; Doo Young Choi; Sang Wook Choi; Yong Mook Choi; Jeong Ok Hah; Pyoung Han Hwang; Tai Ju Hwang

Return

Epidemiology and Clinical Characteristics of Childhood Acute Lymphoblastic Leukemia in Korea.

Author: Kwang Chul LEE ¹ ; Im Joo KANG ; Shin Heh KANG ; Hong Hoe KOO ; Hoon KOOK ; Kir Young KIM ; Moon Kyu KIM ; Soon Kyum KIM ; Hack Ki KIM ; Hwang Min KIM ; Heung Sik KIM ; Seung Kon NAM ; Hyung Nam MOON ; Kyung Duk PARK ; Sae Myung PARK ; Jae Sun PARK ; Jong Young PARK ; Hyun Jin PARK ; Won Suk SUH ; Jong Jin SEO ; Ki Woong SUNG ; Sang Man SHIN ; Hee Young SHIN ; Tae Sub SHIM ; Don Hee AHN ; Hyo Seop AHN ; Chang Hyun YANG ; Eun Suk YANG ; Chan Wook WOO ; Kyung Ha RYU ; Eun Sun YOO ; Chuhl Joo LYU ; Kun Soo LEE ; Soon Yong LEE ; Young Ho LEE ; Hahng LEE ; Young Tak LIM ; Ho Joon IM ; Bin CHO ; Hyun Sang CHO ; Kyu Chul CHOEH ; Doo Young CHOI ; Sang Wook CHOI ; Yong Mook CHOI ; Jeong Ok HAH ; Pyoung Han HWANG ; Tai Ju HWANG
Author Information

1. The Korean Society of Pediatric Hematology-Oncology, Korea. yh951637@chol.com
Publication Type:Original Article
Keywords: Acute lymphoblastic leukemia; Epidemiology; Event free survival; Children
MeSH: Cause of Death; Child; Clinical Protocols; Cytogenetics; Dacarbazine; Diagnosis; Disease-Free Survival; Epidemiology*; Female; Hemorrhage; Humans; Incidence; Kaplan-Meier Estimate; Korea*; Leukemia; Male; Medical Records; Pneumonia; Precursor Cell Lymphoblastic Leukemia-Lymphoma*; Precursor Cells, B-Lymphoid; Recurrence; Retrospective Studies; Sepsis; Treatment Outcome
From:Korean Journal of Pediatric Hematology-Oncology 2002;9(1):9-20
CountryRepublic of Korea
Language:Korean
Abstract: PURPOSE: Acute lymphoblastic leukemia (ALL) accounts for approximately 75% of all cases of childhood leukemia. We investigated epidemiology, clinical and laboratory features and treatment outcome of the children with ALL in Korea during recent 5 years. METHODS: One thousand forty nine patients were enrolled between January 1994 and December 1998 from 37 major hospitals in Korea. The data regarding the clinical and laboratory features including age, WBC counts at diagnosis, immunophenotype, morphology, cytogenetics and treatment outcome of patients were analyzed retrospectively by review of patient's medical records. Kaplan-Meier survival curves were constructed. The differences between groups analyzed by log-rank test. RESULTS: There were 597 males and 452 females. The distribution between the age 2 and 5 years is most common in 46.1%. The annual incidence rate per 100,000 population varied from 1.6 to 2.2. The 5 year event free survival (EFS) rates according to good prognostic factors were as follows: 67% bet ween 1-9 year of age at diagnosis, 69% in under 10,000/mm3of initial WBC count, 74% in early pre-B cell CALLA ( ) immunophenotype, 65% in L3 morphology, 68% in no CNS invasion. Most of patients were treated by CCG treatment protocol. The 5 year EFS was 63%. Main complications were sepsis (21.8%) and hemorrhage (12.5%). The relapse rate was 15.6%. The common causes of death were sepsis, DIC, pneumonia, relapse. CONCLUSION: Our results could provide the most recent and important information about acute lymphoblastic leukemia of children in Korea.