Supplementary Effect of gamma-Oryzanol on Lipid Metabolism in Diabetic KK Mice.
- Author:
Sung Hyeon LEE
1
;
Hye Kyung CHUN
;
Hong Ju PARK
;
Yeon Sook LEE
Author Information
1. Agriproduct Science Division, National Rural Resources Development Institute, NIAST, RDA, Suwon, Korea.
- Publication Type:Original Article
- Keywords:
gamma-oryzanol;
rice bran;
diabetic mouse;
lipid metabolism
- MeSH:
Animals;
Bile;
Body Weight;
Body Weight Changes;
Cholesterol;
Diet;
Feces;
Lipid Metabolism*;
Mice*;
Organ Size;
Oxidoreductases;
Triglycerides
- From:The Korean Journal of Nutrition
2004;37(5):347-351
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
This study was carried out to investigate the supplementary effects of gamma-oryzanol extracted from rice bran on lipid metabolism in diabetic mice. We supplied 2 kinds of experimental diets (CO without and GO with 0.2% gamma-oryzanol) to diabetic mice for 8 weeks. Diet intake, body weight, organ weight, contents of serum and hepatic lipid profiles, and fecal lipid levels were measured. Though there was no significant difference in diet intake, body weight change and organ weight between experimental groups, the concentration of serum total cholesterol and hepatic total lipid, total cholesterol and HMG-CoA reductase activity was significantly lower in GO group treated with 0.2% gamma-oryzanol of diet than CO group after supplementary period of experimental diets. And total lipid, triglyceride, total cholesterol, and bile acid levels excreted to feces were significantly higher in GO group than CO group. These results suggest that gamma-oryzanol decrease the serum and hepatic lipid levels by lowing HMG-CoA reductase activity or increasing the contents of fecal lipid in diabetic KK mice.
