Effects of Ginkgo Biloba Extract on Experimentally Induced Hearing Loss by Noise.
- Author:
Suk Ho LEE
1
;
Tae Hoon KIM
;
Boo Hyun NAM
;
Chan Il PARK
Author Information
1. Department of Otolaryngology, Chungnam National University College of Medicine, Taejeon, Korea. ent107@hanmail.net
- Publication Type:Original Article
- Keywords:
Ginkgo biloba;
Hearing Loss;
Noise-Induced;
Guinea pigs
- MeSH:
Animals;
Brain Stem;
Free Radicals;
Ginkgo biloba*;
Guinea Pigs;
Hearing Loss*;
Hearing*;
Mass Screening;
Noise*;
Platelet Activating Factor
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2001;44(10):1028-1031
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Ginkgo biloba extract (EGb) has been known to have actions of increasing blood flow, free radicals scavenger and platelet activating factor antagonism. The purpose of this study was to evaluate the protective effect of the EGb in an experimentally induced hearing loss by noise. MATERIALS AND METHODS: Ten guinea pigs (EGb treated group and control group) were exposed to a narrow band noise (3,760-4,280 Hz), 6 hours daily for 6 days. An auditory evoked brainstem response (ABR) threshold was measured daily before and after a noise exposure. Two animals in each groups were sacrificed for a scanning electron microscopic (SEM) screening. RESULTS: The EGb treated group showed less changes in ABR threshold and SEM findings compared the control group. CONCLUSION: These findings suggest that the EGb may have a protective effect in noise induced hearing loss.
