Immunohistochemical Study on Platelet-Derived Growth Factor alpha-Receptor (PDGF-alphaR) in the Canine Cerebellum During Postnatal Development.
- Author:
Sang Pil YOON
1
;
Jeong Seok MOON
;
Jong Joong KIM
;
Young YOON
;
Ho Jin YOU
;
Ha Young CHO
;
In Youb CHANG
Author Information
1. Department of Anatomy, College of Medicine, Chosun University, Korea. iyjang@mail.chosun.ac.kr
- Publication Type:Original Article
- Keywords:
PDGF-alphaR;
Immunohistochemistry;
Postnatal development;
Cerebellum;
Dog
- MeSH:
Animals;
Cerebellum*;
Chemotaxis;
Dogs;
Immunohistochemistry;
Nervous System;
Neurons;
Platelet-Derived Growth Factor*;
Purkinje Cells
- From:Korean Journal of Anatomy
2001;34(5):495-501
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The biological activities of PDGF include stimulation of mitogenesis, chemotaxis, and differentiation. In nervous system, previous studies have shown that PDGF has an important role in the generation of cells of a glial lineage. However, several studies demonstrated that mature and immature neurons could also synthesize PDGF-alphaR. In the present study, to analyze the distributional pattern of PDGF-alphaR during postnatal development of the canine cerebellum, we used immunohistochemistry. We found that neurons of cerebellum, including Purkinje cells and granules cells, showed immunoreactivity to PDGF-alphaR (IRPDGF-alphaR) as early as postnatal day 0. Whereas IRPDGF-alphaR immunoreactivity in the Purkinje cells were maintained at all postnatal ages. Our data support that PDGF may have the important roles during development and survival of neurons.
