Influence of 0.2mg Tamsulosin Treatment on the Erectile and Ejaculatory Functions in Patients with Benign Prostatic Hyperplasia.
10.4111/kju.2007.48.12.1251
- Author:
Sang Hoon SONG
1
;
Hwancheol SON
;
Jae Seung PAICK
Author Information
1. Department of Urology, Seoul National University Hospital, Seoul, Korea. volley@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Tamsulosin;
Benign prostatic hyperplasia;
Erectile function;
Ejaculation
- MeSH:
Ejaculation;
Humans;
Male;
Orgasm;
Prostate;
Prostate-Specific Antigen;
Prostatic Hyperplasia*;
Prostatic Neoplasms;
Questionnaires;
Ultrasonography;
Urinalysis;
Urinary Bladder, Neurogenic
- From:Korean Journal of Urology
2007;48(12):1251-1257
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The aim of this study was to evaluate the influence of 8 weeks of 0.2mg tamsulosin medication on the erectile and ejaculatory functions of patients with benign prostatic hyperplasia(BPH). MATERIALS AND METHODS: 108 patients with BPH and they were without prostate cancer and neurogenic bladder were included in this study. Initial evaluations included a thorough history, digital rectal exam, urinalysis, serum prostate-specific antigen, uroflowmetry(UFM), post void residual urine measurement, transrectal ultrasound, International Prostatic Symptom Score(IPSS) and an International Index of Erectile Function(IIEF) and ejaculatory function questionnaire. After 4 and 8 weeks of medication, we analyzed the differences of these parameters at each week. RESULTS: The mean age of the patients was 61.3+/-9.0 years old and their prostate volume was 35.7+/-21.3ml. The IIEF erectile function(EF) domain score showed no statistically significant difference after medication. However, the orgasmic function domain score showed a significant decrease from 16.3+/-9.3 to 15.7+/-9.6 at the 4th and 8th week. Regarding the ejaculatory function, when the patients were divided into two groups according to the EF domain score(<10, > or =11), the score of the ejaculatory volume showed a tendency to decrease from 2.5+/-1.0 to 2.2+/-1.2(p=0.07), and the score for satisfaction about ejaculation was decreased from 3.0+/-1.2 to 2.5+/-1.5(p=0.01) in the larger EF domain group after 8 weeks of treatment. The IPSS score and UFM parameters improved significantly after medication(p<0.05). CONCLUSIONS: For the patients with BPH, 8 weeks of 0.2mg tamsulosin medication caused significant improvement in their voiding function. In addition, our findings suggest that 0.2mg tamsulosin medication may the influence erectile and ejaculatory function.
