Autogenous Mucosa-Lined Tracheal Prosthesis.
- Author:
Chung Hwan BAEK
1
;
Jong Chan LEE
;
Juno SHIN
;
Kwang Chol CHU
;
Hojoong KIM
;
Soo Won SUH
;
Jhingook KIM
Author Information
1. Department of Otorhinolaryngology-Head and Neck Surgery, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Tracheal prosthesis;
Prolene mesh;
Autologous mucosa transplantation;
Omental wrapping
- MeSH:
Adult;
Animal Experimentation;
Animals;
Constriction, Pathologic;
Dogs;
Gelatin;
Humans;
Mouth Mucosa;
Mucous Membrane;
Omentum;
Phenobarbital;
Polypropylenes;
Prostheses and Implants*;
Trachea;
Transplants
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2000;43(4):416-420
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Reliable prosthetic or tissue graft of trachea for reconstruction of large, circumferential tracheal defect has not yet been developed. The major limitations in this area have been anastomotic dehiscence and stenosis, which are attributed to poor epithelialization and vascularization of prosthetic grafts. MATERIALS AND METHOD: We developed a new tracheal prosthesis which has a viable lined mucosa and is well-vascularized. The prosthesis consists of Prolene mesh reinforced with polypropylene rings, and is coated with gelatin. We lined the luminal surface of the prosthesis with transplanted autogenous oral mucosa and wrapped the prosthesis with greater omentum. Animal experiments were performed using 8 adult Mongrel dogs. RESULTS: The transplanted mucosa and the greater omentum that was wrapped were tightly adhered to the prosthesis to make a single unit within two weeks. The mucosa survived well, having been vascularized by new vessels from the greater omentum, and showed normal histology. CONCLUSION: We concluded that this highly biocompatible tracheal prosthesis could be very useful for stage4 reconstruction of tracheal defects.
