Effect of Salicylate on DPOAEs and ABRs in Guinea Pigs.
- Author:
O Young LEE
1
;
Yong Ho PARK
;
Suk Ho LEE
;
Boo Hyun NAM
;
Chan Il PARK
Author Information
1. Department of Otolaryngology, College of Medicine, Chungnam National University, Daejeon, Korea.
- Publication Type:Original Article
- Keywords:
Salicylates;
Hearing loss;
Audiometry;
Guinea pigs
- MeSH:
Animals;
Audiometry;
Cochlea;
Ear;
Guinea Pigs*;
Guinea*;
Hair;
Hearing Loss;
Injections, Intraperitoneal;
Salicylates;
Sodium Salicylate;
Tinnitus
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2002;45(7):646-650
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Salicylates are well-known for producing reversible hearing loss and tinnitus. However, the site and mechanism of salicylate ototoxicity remain unresolved. Recent experiments suggest that reversible biochemical and/or metabolic changes in the cochlea seem to play an important role in salicylate ototoxicity. The purpose of this study was to investigate the site of lesion in salicylate ototoxicity by audiometric study. MATERIALS AND METHOD: ABRs and DPOAEs were observed after intraperitoneal injection of 500 mg/kg of sodium salicylate on 24 ears of guinea pigs. RESULTS: Salicylate produced a significant increase in the ABR threshold. Maximum changes were obtained in 4 hours, and recovered to the baseline in 24 hours after salicylate administration. The pattern of hearing loss shown by latency-intensity function was compatible with the cochlear type of hearing loss. The echo amplitude on DPOAEs at f2=2002, 4004 Hz was significantly decreased at 2, 4, 6, 8 hours, and returned to the baseline in 24 hours after salicylate administration. The time course of the change of DPOAEs was parallel with that of ABRs. CONCLUSION: These results reflect that the cochlear outer hair cells may be the main site of lesion in salicylate ototoxicity.
