Joint Symptoms in Henoch - Schonlein Purpura.
- Author:
Joo Hyoun SONG
;
Yong Koo KANG
;
Han Young LEE
;
Hae Seok KOH
;
Kee Won RHYU
;
Sang Young SHIN
- Publication Type:Original Article
- Keywords:
Henoch - Sch nlein purpura;
Joint symptom;
HLA - typing
- MeSH:
Abdominal Pain;
Ankle;
Arthralgia;
Arthritis;
Arthritis, Rheumatoid;
Child;
Female;
Fever;
Follow-Up Studies;
Hematuria;
Histocompatibility Testing;
Humans;
Joints*;
Knee;
Leukocytosis;
Male;
Mass Screening;
Purpura*;
Seasons;
Vasculitis
- From:The Journal of the Korean Orthopaedic Association
1998;33(5):1475-1480
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Henoch-Sch nlein purpura is a small-vessel vasculitis characterized by palpable purpura, abdominal pain, hematuria and arthralgia. Joint involvement occurs in 2/3 of the cases and the joint symptoms are misapprehended as an orthopaedic problem because they are often severe and occurs before characteristic purpura. It has been reported that the joint symptoms can be improved without any sequelae. But, recently some authors suggest that severe joint destruction can occur when combined with rheumatoid arthritis and the patients are FILA-DR4 positive. So, the regular follow-up for joint symptoms and screening test for the risky patients having possibility for progression of arthritis are required. In order to increase the attention of the orthopaedic surgeons on this disease and study the progression of joint symptoms, possibility of development of screening test for the risky patients and the characterisitics of the disease, we analyzed the 58 patients of Henoch-Sch nlein purpura. The following results were obtained. Among 58 patients 34 cases were male and 25 cases were female, 5 to 10-year-old children were affected more frequently and the disease occurs frequently in spring and winter season. Joint symptoms developed in 22/58 patients(37.9%) and occurs before characteristic purpura in 5/22 patients(22.7%) among the joint symptom-developed patients. Knee and ankle were affected in most patients and the inflammatory signs such as high fever, leukocytosis and elevated ESR were accompanied with joint symptom, so it resembled the symptoms and signs of pyogenic arthritis. Most of the patients recovered without remaining sequelae but 9 patients(15.5%) among joint symptom-developed patients complained repeated attacks of arthralgia. The HLA B27 were all positive in those patients. So, it was assumed that the joint symptom in Henoch-Sch nlein purpura has a correlation with genetic environment and through the broad prospective study, the HLA typing can be a screening test for the risky group prone to suffer from repeated attack or aggravation of arthritis.
