Effect of Korean Traditional Tea Materials Water Extract on Hepatic Oxygen Free Radical Generating and Scavenging Enzyme Activities in Lead Administered Rats.
- Author:
Duk Jin KIM
1
;
Soo Yeul CHO
;
Kyong Hee SHIN
;
Mi Kyung LEE
;
Myung Joo KIM
Author Information
1. Division of Food, Bilogical and Chemical Engineering, Daegu University, Gyeongsan, Korea.
- Publication Type:Original Article
- Keywords:
tea materials;
lead;
oxygen free radical metabolism
- MeSH:
Aminopyrine N-Demethylase;
Animals;
Carthamus tinctorius;
Catalase;
Diospyros;
Eucommiaceae;
Glucose;
Glutathione;
Glutathione Peroxidase;
Glutathione Transferase;
Humans;
Liver;
Male;
Metabolism;
Monoamine Oxidase;
Oxidoreductases;
Oxygen*;
Rats*;
Reactive Oxygen Species;
Superoxide Dismutase;
Tea*;
Water*;
Xanthine Oxidase
- From:The Korean Journal of Nutrition
2003;36(2):117-124
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
This study was designed to test the effect of Korean traditional tea materials on oxygen-free radical metabolism in lead (Pb) -administered rats. Male rats were divided into normal, Pb-control (Pb-Con) and Pb-water extract of green tea (Camellia sinensis; GT) , persimmon leaf (Diospyros kaki; PL) , safflower seed (Carhamus tinctorius: SS) , Du-Zhong (Eucommia ulmoides; EU) groups, respectively. Pb intoxication was induced by administration of lead acetate (25 mg/kg. B.W., oral) weekly. The extract was administered based on 1.26 g of raw material/kg B.W./day for 4 weeks. When the GT, PL, SS and EU were supplemented to the Pb-administered rats, hepatic lipid peroxide levels were significantly lower compared to the Pb-Con group. Hepatic cytochrom P-450 content and aminopyrine N-demethylase activity was lower in the Pb-Con group than in the normal group, whereas xanthine oxidase activity was significantly elevated in Pb-administered rats. The water extract of GT, PL, SS and EU supplementation attenuated changes in enzyme activities generating reactive oxygen species in the liver. Hepatic superoxide dismutase, catalase and glucose 6-phosphate dehydrogenase activities were significantly higher in the Pb-Con group than in the normal group, while monoamine oxidase activity also tended to increase in the Pb-administered rats. However, glutathione peroxidase and glutathione S-transferase activities, and glutathione content significantly decreased through Pb intoxication. The supplementation of GT, PL, SS and EU induced alleviation changes of hepatic antioxidant enzyme activity.