Apolipoprotein E Polymorphism in Ischemic and Hemorrhagic Stroke.
- Author:
Hyon Ah YI
1
;
Jeong Geun LIM
;
Oh Dae KWON
;
Yong Won CHO
;
Hyung LEE
;
Sang Doe YI
;
Dae Kwang KIM
Author Information
1. Department of Neurology, Keimyung University School of Medicine, Daegu, Korea. dkkim@dsmc.or.kr
- Publication Type:Original Article
- Keywords:
Apo E allele;
Polymorphism;
Ischemic stroke;
Hemorrhagic stroke
- MeSH:
Alleles;
Apolipoproteins E;
Apolipoproteins*;
Arteries;
Atherosclerosis;
Carotid Arteries;
Carotid Stenosis;
Cerebral Hemorrhage;
Coronary Artery Disease;
Gene Frequency;
Genotype;
Heart Diseases;
Humans;
Hypertension;
Polymerase Chain Reaction;
Risk Factors;
Stroke*
- From:Korean Journal of Anatomy
2002;35(4):355-361
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
There is an evidence for a role of apolipoprotein E (APOE) in atherosclerosis, coronary heart disease and carotid artery stenosis. Morbidity of carotid artery atherosclerosis is higher in persons carrying an epsilon4 allele, but the association of cerebrovascular disease and apoE genotype is controversial. We studied the association between APOE genotype and allele (epsilon2, epsilon3, epsilon4) frequency and stroke. We evaluated APOE genotype in 133 first -ever stroke patients and 111 healthy controls. We also estimated the risk factors of stroke such as hypertension, diabetes and lipid profiles in both groups. APOE genotypes were analyzed by polymerase chain reaction. APOE genotypes and allele distributions were not different in patients and controls. There is also no difference of APOE allele frequencies between ischemic small artery occlusive disease and hypertensive subcortical intracerebral hemorrhage. We concluded that the APOE -epsilon4 allele is not associated with stoke including ischemic and hemorrhagic stroke.
