Low Blood Selenium Concentrations in Critically Ill Children with Systemic Inflammatory Response Syndrome and Respiratory Dysfunction.
10.4266/kjccm.2013.28.2.86
- Author:
Young A KIM
1
;
Eun Ju HA
;
Won Kyoung JHANG
;
Seong Jong PARK
Author Information
1. Division of Pediatric Critical Care Medicine, Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea. drpsj@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
blood selenium concentration;
critically ill children;
respiratory dysfunction;
systemic inflammatory response syndrome
- MeSH:
Child;
Critical Illness;
Humans;
Intensive Care Units;
Platelet Count;
Retrospective Studies;
Selenium;
Sepsis;
Shock, Septic;
Systemic Inflammatory Response Syndrome
- From:The Korean Journal of Critical Care Medicine
2013;28(2):86-92
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Selenium is an essential trace-element with antioxidant and immunological function. We studied the relationship between blood selenium concentrations, systemic inflammatory response syndrome (SIRS) and organ dysfunctions in critically ill children. METHODS: This was a retrospective, observational study of the blood selenium concentrations of critically ill children at the time of a pediatric intensive care unit admission. RESULTS: A total of 62 patients with a median age of 18 (5-180) months were included in this study. The mean of blood selenium concentration (microg/dl) was 8.49 +/- 2.42. The platelet count (r = -0.378) and PaCO2 (r = -0.403) showed negative correlations with blood selenium concentration, while PaO2/FiO2 (r = 0.359) and PaO2 (r = 0.355) showed positive correlations (p < 0.05, for all variables). Blood selenium concentrations were significantly lower in patients with SIRS than in those patients without SIRS (8.08 +/- 2.42 vs. 9.45 +/- 2.02, p = 0.011). Patients with severe sepsis and septic shock had showed significantly lower blood selenium concentrations than those without SIRS (7.03 +/- 2.73 vs. 9.45 +/- 2.02, p = 0.042). Patients with PaO2/FiO2 < or = 300 had lower blood selenium concentrations than those with PaO2/FiO2 > 300 (7.90 +/- 2.43 vs. 9.54 +/- 2.17, p = 0.018). Blood selenium concentrations were significantly lower in patient with PaO2/FiO2 < or = 200 than in those with PaO2/FiO2 > 300 (7.64 +/- 2.76 vs. 9.54 +/- 2.17, p = 0.018). CONCLUSIONS: Patients with systemic inflammatory response syndrome or respiratory dysfunction showed significantly low blood selenium concentrations.
