The Growth Inhibitory Effects of Atrina Pecitinata Fractions on Cancer Cell Lines.
- Author:
Soung Young PARK
1
;
Mi Ok SHIN
;
Sang Hyun LEE
;
Song Ja BAE
Author Information
1. Department of Food and Nutrition, Biotechnology, Korea.
- Publication Type:In Vitro ; Original Article
- Keywords:
cytotoxicity;
quinone reductase;
Atrina pecitinata
- MeSH:
Cell Line*;
Hep G2 Cells;
Humans;
Methanol;
NAD(P)H Dehydrogenase (Quinone)
- From:The Korean Journal of Nutrition
2005;38(4):307-312
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We investigated the growth inhibitory effects of Atrina pecitinata (AP) on the proliferation in human cancer cell lines in vitro. AP was extracted with methanol which was further fractionated into four diffferent types: methanol (APMM), haxane (APMH), butanol (APMB), and aquous layers (APMA). Among various partition layers, the APMM showed the strongest cytotoxic effects on all cancer cell lines which we used. In the MTT assay of AP fractions, the growth inhibitory effects was increased in proportion to its concentration. We observed quinone reductase (QR) induced effects in all fraction layers of AP on HepG2 cells. The QR induced effects of APMM on HepG2 cell at 80 microgram/mL concentration indicated 2.0 with a control value of 1.0.
