Cyclooxygenase-2 and choroidal neovascularization
10.3969/j.issn.1003-0808.2010.01.023
- VernacularTitle:环氧化酶-2与脉络膜新生血管
- Author:
Yan, CAI
;
Yusheng, WANG
- Publication Type:Journal Article
- Keywords:
choroidal neovascularization;
cyclooxygenase-2;
vascular endothelial growth factor
- From:Chinese Ophthalmic Research
2010;28(1):86-89
- CountryChina
- Language:Chinese
-
Abstract:
Choroidal neovascularization(CNV)is one of common causes of vision loss.The pathogenesis and development of CNV are a comprehensive process which is regulated by multiple factors and cytokines.Cyclooxygenase-2(COX-2)is an inducible isoform of cyclooxygenase and rate limiting enzyme in the prostaglandin biosynthesis pathway.COX-2 plays an important role in neovascularization by modulating vascular endothelial growth factor(VEGF),migration and apoptosis of endothelial cell.Recently,some experimental studies demonstrated that COX-2 involves in the information of CNV and the inhibitor of COX-2 can suppress CNV.These results provide a new prospect for the prevention and treatment of the CNV.Biological characteristics of COX-2 and its relationship with CNV are reviewed in this article.
