Malignant inverted papilloma of the urinary bladder: the histopathological aspect of malignant potential of inverted papilloma.
10.3346/jkms.1995.10.2.103
- Author:
Jun CHEON
1
;
Han Kyeom KIM
;
Je Jong KIM
;
Duck Ki YOON
;
Sung Kun KOH
;
In Sun KIM
Author Information
1. Department of Urology, Korea University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- MeSH:
Adult;
Bladder Diseases/pathology;
Bladder Neoplasms/chemistry/*pathology;
Cell Division/physiology;
Cell Transformation, Neoplastic/pathology;
Female;
Human;
Male;
Middle Age;
Nitrosourea Compounds/analysis;
Nucleolus Organizer Region/chemistry;
Papilloma, Inverted/chemistry/*pathology;
Receptor, erbB-2/analysis;
Silver Staining
- From:Journal of Korean Medical Science
1995;10(2):103-110
- CountryRepublic of Korea
- Language:English
-
Abstract:
To investigate the histopathological characteristics of inverted papillomas of the urinary bladder, including the possibility of malignant transformation, we studied the indicators of cellular proliferation activity in 7 inverted papillomas of the bladder including two cases of malignant inverted papilloma of the bladder. PCNA expression rates in two cases of malignant inverted papilloma were higher than in benign inverted papillomas. Mean numbers of AgNORs per nucleus in malignant inverted papillomas were much more than in benign inverted papillomas. The c-erbB-2 oncoprotein was expressed only in malignant inverted papillomas. These results suggest that PCNA expression rate, mean number of AgNORs per nucleus and c-erB-2 oncoprotein expression may be merited as good indicators to detect the inverted papilloma with more proliferative and aggressive lesions, and with the potential of malignant transformation.
