Changes of the femur biomechanics in fluorosis rats
10.3760/cma.j.issn.1000-4955.2009.02.010
- VernacularTitle:氟对大鼠股骨生物力学性质改变的影响
- Author:
Jing-yan, LI
;
Zi-ping, LIANG
;
Hong-shun, MA
- Publication Type:Journal Article
- Keywords:
Fluorosis;
Rats;
Femur;
Mechanical properties
- From:Chinese Journal of Endemiology
2009;28(2):154-156
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of femur biomechanical properties in fluorosis rats. Methods Fifty Wistar rats of thirty-day old, weighing 90-100 g, were randomly divided according to body mass into fluorosis and control group of 25 each. Fluorosis group drank tap water containing 100 mg/L of fluoride, the control group drank tap water. The rats were observed of dental growing status and killed after feeding 6 months. Their femurs underwent tensile strength, impact, shear, bending experiments. Results The deteetable rate of dental fluorosis was significantly higher in fluorosis group[92%(23/25)] than control group[0(0/25),X2=38.97, P<0.01]. Biomeehanical data in fluorosis group(225.67±11.81,1.94±0.15,76.62±6.10,39.96.3±3.90) were lower than those of the control group(244.70±13.38,2.39±0.19,87.72±7.05,45.75±3.75) in experiments of tensile strength (MPa), impact toughness (J/mm2), shear and bending strength (MPa). The difference was statistically significant(t=3.372,5.879,3.756 and 3383, respectively, P<0.01) between the two groups. Conclusion Fluorides affected bone metabolism in rats, femur biomechanieal properties ehanged in fluorosis rats.
