The association of TNF-β polymorphism with idiopathic dilated cardiomyopathy(IDC) in Northern Chinese Han population

VernacularTitle:肿瘤坏死因子-β基因多态性与特发性扩张性心肌病的相关性分析
Author: Min, SUN ; Ya-Li, ZHANG ; Li, GUAN
Publication Type:Journal Article
Keywords: Cardiomyopathy,dilated; Tumor necrosis factors; Genes; Genetic predisposition to disease
From:Chinese Journal of Endemiology 2009;28(2):165-167
CountryChina
Language:Chinese
Abstract: objective To study the relationships between TNF-β gene type in idiopathic dilated cardiomyopathy (IDC). Methods Eighty-six IDC patients were chosen as IDC group and 95 cases unrelated healthy people as control group in the First Hospital of Jilin University in 2008. The levels of TNF-β protein were detected with Enzyme-linked immunosorbent assay(ELISA ). TNF-β polymorphism were analyzed by polymerase chain reaction-restriction fragment length polymorphisms(PSR-RFLP). Results The levels of TNF-β protein in IDC patients[(1.876±1.013) μ/L] were significantly higher than controls[(1.018±0.645)μg/L], the difference being statistically significant (t=2.674,P<0.01). The frequency of TNFβ*2 genotypes in IDC patients[63.4%(109/172] was significantly higher than controls[47.9%(91/190)], the difference being statistically significant(OR=1.88, X2=6.78, P<0.05). Conclusions The TNFβ*2 allele might related to idiopathic dilated cardiomyopathy (IDC), can also be considered as one of susceptible genes of IDC