Investigation of state and influence factors of children's Kaschin-Beck disease in Xinghai county of Qinghai province in 2009
10.3760/cma.j.issn.1000-4955.2012.04.020
- VernacularTitle:2009年青海省兴海县儿童大骨节病病情及影响因素调查
- Author:
Fan-gang, MENG
;
Qiang, LI
;
Ying, FU
;
Zhi-jun, ZHAO
;
Ling-wang, ZHOU
;
Hu, WANG
;
Hui, LIU
;
De-an, LI
;
Li-hua, WANG
- Publication Type:Journal Article
- Keywords:
Kaschin-Beck disease;
Selenium;
T-2 toxin
- From:Chinese Journal of Endemiology
2012;31(4):426-429
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the present prevalence state of children's Kaschin-Beck disease (KBD) in Xinghai county of Qinghai province,a relative active KBD area in 2009,and to investigate their nutritional selenium level of local children and the T-2 toxin contamination level in their staple food.Methods Right hand X-ray photographs of children aged 7 - 12 in Shang,Zhong and Xia villages of Tangnaihai countryside in Xinghai county were taken.X-ray diagnosis was carried out according to the Diagnostic Criteria of Kashin Beck Disease (GB 16003-1995 ).Selected samples (children's hair,drinking water and their staple food) were collected according to X-ray film taken.Selenium contents in hair,drinking water and staple food samples were measured by 2,3-diaminonaphthalene fluorescence,and T-2 toxin in staple food sample was detected with enzyme-linked immunosorbent assay(ELISA) kits.ResultsTotal X-ray detection rate of children KBD was 12.20％(31/254) and KBD positive rate of children in Xia village was up to 14.97％(22/147),Shang village was up to 9.52％(6/63),and Zhong village was up to 6.82％ (3/44).The selenium level in children's body and outer environment was very low,namely,the selenium content in hair,drinking water,wheat and flour was (0.250 ± 0.136)mg/kg,(0.156 ± 0.046)μg/L,(0.0045 ± 0.0030)mg/kg,and (0.0067 ± 0.0116)mg/kg,respectively.The T-2 toxin level was relatively high in children's staple food,which was (78.91 ± 46.17)μg/kg in wheat and (47.47 ± 46.47)μg/kg in flour.Conclusions In relative active KBD areas of Xinghai county of Qinghai province,the children's selenium nutritional level is low,and the T-2 toxin contamination level in their staple food is relatively high,which is consistent with the distribution of local children's KBD.
