Correlation between single nucleotide polymorphism H558R in SCN5A gene and chronic Keshan Disease complicated with hypertension, and their electrocardiogram characteristics
10.3760/cma.j.issn.1000-4955.2012.04.008
- VernacularTitle:SCN5A基因单核苷酸多态性位点H558R 与慢型克山病合并高血压及其心电图特征的相关性研究
- Author:
Shan, JIANG
;
Chuan-feng, FANG
;
Han-wen, LIU
;
Chang, SHU
;
He, CHENG
;
Juan, HE
;
Feng-lan, LI
;
Hui, LI
- Publication Type:Journal Article
- Keywords:
Keshan disease;
Single nucleotide polymorphism;
SCN5A gene;
Arrythmia
- From:Chinese Journal of Endemiology
2012;31(4):377-380
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To investigate the relationship between single nucleotide polymorphism (SNP)H558R in SCN5A gene and chronic Keshan disease (KSD) complicated with hypertension,and the relationship between H558R and occurrence of arrythmia in chronic KSD complicated with hypertension.MethodsThirty nine patients with chronic KSD complicated with hypertension and 63 geographical region matched hypertension control subjects were recruited in our study in Fuyu county,Qiqihaer city,Heilongjiang province between 2006 and 2010.H558R polymorphism in case and control groups was genotyped using the polymerase chain reaction single-strand conformation polymorphism(PCR-SSCP) and sequenced,and electrocardiography(ECG) characteristics were examined in the two groups.Case-control study analytical methods were applied to analyze the relationship between H558R and chronic KSD complicated with hypertension,and the relationship between H558R and occurrence of arrythmia in chronic KSD patients complicated with hypertension.Results Subjects of genotype 558 TC in the case group had a decreased risk of chronic KSD complicated with hypertension with odds ratio of 0.288[95％ confidence interval (CI):0.104 - 0.794],and subjects of genotype TC in chronic KSD complicated hypertension patients had a decreased risk of QRS prolongation with odds ratio of 0.061 (95％CI:0.006 - 0.612).Conclusions Polymorphism H558R in SCN5A gene may be a predisposition factor of chronic KSD complicated with hypertension and occurrence of arrythmia in chronic KSD complicated with hypertension.
