Analysis on the reasons for diffuse 18F-FDG uptake by bone marrow using whole-body PET/CT

VernacularTitle:18F-FDG PET/CT显像全身骨髓代谢弥漫增高原因分析
Author: Ji-lin, YIN ; Xin-lu, WANG ; Jin-he, ZHANG ; Yu, LIU ; Wei-biao, ZHANG ; Xi, OUYANG
Publication Type:Journal Article
Keywords: Bone marrow; Tomography,emission-computed; Tomography,X-ray computed; Deoxyglucose
From:Chinese Journal of Nuclear Medicine 2011;31(3):151-154
CountryChina
Language:Chinese
Abstract: Objective To analyze the causes for diffuse bone marrow uptake of 18F-FDG on PET/CT scans. Methods Sixty-six patients with diffuse bone marrow uptake on whole-body FDG-PET/CT imaging were enrolled for this study. Seventy-nine healthy subjects ( with no history of tumor or recent fever) were selected as normal control. The SUVmax and SUVmean were measured in bone marrow and mediastinum in both groups. The maximum (bone marrow SUVmax/ mediastinum SUVmax) and mean value ratios (bone marrow SUVmean/ mediastinum SUVmean) were calculated. Statistical analysis was performed by one-factor variance analysis. Results With diffuse bone marrow uptake pattern of 18F-FDG, 27 were caused by injection of hematopoietic growth factor, 21 by hematopathy and 18 due to fever. SUVmeanof those three causes were 3.076±1.955, 3.633±2.405 and 2.546±0.791 respectively, each was significantly different from that of the control group (1.026±0.190; F =34.465, P<0.001). Conclusion Diffuse bone marrow uptake on FDG-PET/CT are caused by both benign and malignant reasons.