The precision of glomerular filtration rate determined by Gates method and compared with the results from renal pathological changes
10.3760/cma.j.issn.0253-9780.2011.02.015
- VernacularTitle:Gates法测定肾小球滤过率的精确性及与病理对照分析
- Author:
Peng-cheng, HU
;
Hong-cheng, SHI
;
Yu-shen, GU
;
Shuguang CHEN
;
Yan, XIU
;
Bei-lei, LI
;
Wei-min, ZHU
- Publication Type:Journal Article
- Keywords:
Kidney diseases;
Glomerular filtration rate;
Radionuclide imaging;
DTPA
- From:Chinese Journal of Nuclear Medicine
2011;31(2):134-137
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the precision of GFR using Gates method and compared with the results from renal pathological changes. Methods Twenty-seven patients whose 99Tcm-DTPA renograms had no obvious uptake phase were enrolled in Group A, and 27 patients whose 99Tcm-DTPA renograms had obvious uptake phase were enrolled in Group B. The measurement of GFR by Gates method was compared to the creatinine clearance measured and predicted by Cockroft-Gault (C-G), modification of diet in renal disease (MDRD) and SCr level. Renal pathological changes in two groups were compared using Pearson correlation and t test analysis. Results In Group A, GFR determined by Gates method did not show correlation with that estimated by C-G or 1/SCr (r = 0. 357,0. 376, both P ＞0.05), but was significantly correlated with GFR estimated by MDRD(r = 0. 440, P ＜ 0.05). In Group B, GFR determined by Gates method showed significantly correlation among GFR estimated by MDRD, C-G, and 1/SCr (r =0. 471, 0. 527,0. 452, all P ＜ 0.05). Renal tubulointerstitial damage score in Group A was higher than that in Group B (7.15±2.32, 3.70±3.06, t=4.66, P ＜0.001). Conclusions GFR determined by Gates method is less precise when 99Tcm-DTPA renogram has no obvious uptake phase than that when 99Tcm-DTPA renogram has obvious uptake phase. Renal tubulointerstitial damage is a strong indicator of no obvious uptake phase in 99Tcm-DTPA renogram.
