18F-FDG uptake changes in the brain functional loop in patients with refractory obsessive compulsive disorder
10.3760/cma.j.issn.0253-9780.2011.05.004
- VernacularTitle:难治性强迫症的脑内18F-FDG摄取变化及其异常脑功能环路研究
- Author:
Chun, QIU
;
Yi-hui, GUAN
;
Li-min, CHEN
;
Bo-min, SUN
;
Dian-you, LI
;
Zhe-min, HUANG
;
Jun, ZHAO
;
Chuan-tao, ZUO
- Publication Type:Journal Article
- Keywords:
Obsessive-oompulsive disorder;
Brain;
Tomography,emission-computed;
Deoxyglucose
- From:Chinese Journal of Nuclear Medicine
2011;31(5):293-296
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the glucose metabolic pattern of brain functional loop in patients with refractory obsessive compulsive disorder (OCD) using 18 F-FDG PET.Methods Eight patients with refractory OCD and 8 age- and gender-matched healthy volunteers underwent 18F-FDG PET brain imaging.SPM software was used for image post-processing and quantitative analysis.Correlation analysis between 18F-FDG uptake and Yale-Brown obsessive compulsive scale(Y-BOCS) score was performed.Results Compared with the controls,the glucose metabolism of bilateral frontal cortices ( including the rectal gyrus,orbital gyrus and cingulate gyrus),left thalamus,right temporal lobe and bilateral cerebellum in refractory OCD patients increased significantly ( Zmax =3.45 - 5.80,all P ＜ 0.001 ).Bilateral motor cortices and bilateral parietal lobes (BA7),however,showed decreased glucose metabolism (Zmax =3.44 - 4.46,all P ＜0.001 ).Y-BOCS score was positively correlated with the glucose metabolism of the bilateral anterior cingulate cortex (Zmax =3.77,3.48 and 2.97,all P ＜ 0.01 ).Conclusions There is a characteristic metabolic pattern of increased glucose utilization in the fronto-striato-thalamic loop and decreased glucose utilization in bilateral motor cortices and parietal lobes in patients with OCD.The glucose metabolism in the anterior cingulate cortex might serve as a quantitative parameter for the assessment of the severity of OCD.
