Detection of sarcoglycanopathy with 99Tcm-MIBI gated myocardial perfusion imaging
10.3760/cma.j.issn.0253-9780.2011.05.010
- VernacularTitle:肌聚糖病的99Tcm -MIBI门控心肌灌注断层显像评价
- Author:
Ling-ge, WEI
;
Peng, FU
;
Fang, ZHANG
;
Jian-min, HUANG
;
Xiao-mei, LIU
;
Jing, HU
- Publication Type:Journal Article
- Keywords:
Muscular dystrophy;
Myocardium;
Tomography,emission-computed,single-photon;
MIBI
- From:Chinese Journal of Nuclear Medicine
2011;31(5):317-319
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical value of 99Tcm-MIBI gated G-MPI in detecting the myocardial damage in sarcoglycanopathy.Methods 99 Tcm - MIBI G - MPI was performed in 8 patients (3 males,5 females,age ranged from 10 to 30 y) with sarcoglycanopathy confirmed by clinical results and molecular pathology and 4 healthy persons as control group.Quantitative gated SPECT (QGS) software was used for processing and interpretation.Myocardium of left ventricle was divided into 7 segments and 20 subsegments.A five-point scoring system was used to evaluate the myocardial damage.Results Seven patients showed positive results in G-MPI (7/8).Fifty-nine sub-segments of injured myocardium were detected in the 140 sub-segments of 7 abnormal patients.One abnormal segment was observed in 1 patient,two abnormal segments were detected in 2 patients,and ≥3 abnormal segments were observed in 4 patients.Enlarged left ventricles were detected in 5 patients (5/8),and the LVEF of 3 patients among them decreased to (43.1 ±2.8)％.Conclusion 99Tcm-MIBI G-MPI can detect myocardial damage in sarcoglycanopathy as a direct and non-invasive method,and can be used in the early diagnosis and long-term follow-up in sarcoglycanopathy.
