The prognostic value of metabolic tumor volume in FDG PET/CT evaluation of post-operative survival in patients with esophageal squamous cell cancer
10.3760/cma.j.issn.0253-9780.2011.06.007
- VernacularTitle:FDG PET/CT代谢体积对食管癌术后预后的预测价值
- Author:
Wan-qi, ZHU
;
Jin-ming, YU
;
Xiao-rong, SUN
;
Li-gang, XING
;
Peng, XIE
;
Xin-dong, SUN
;
Hong-bo, GUO
;
Guo-ren, YANG
;
Li, KONG
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasms;
Prognosis;
Tomography,emission-computed;
Tomography,X-ray computed;
Deoxyglucose
- From:Chinese Journal of Nuclear Medicine
2011;31(6):378-381
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the prognostic value of MTV on 18F-FDG PET/CT in patients with esophageal cancer.MethodsForty-nine patients with esophageal cancer underwent 18 F-FDG PET/CT scan before surgery.The median follow-up time for the patients was 29 months (range,8- 57 months).The prognostic significance of MTV,age,sex,histologic grade,SUVmax of the primary tumor,tumor size measured on PET/CT,T stage,N stage,M stage,American Joint Committee on Cancer (AJCC) stage,number and location of lymph nodes metastases were assessed by Kaplan-Meier analysis and multivariate Cox model.ResultsIn the univariate analysis,AJCC stage (x2 =16.206,hazard ratio (HR) =1.177,P ＜0.001),N stage (x2 =9.536,HR =10.833,P =0.002),T stage (x2 =5.810,HR=2.397,P=0.016),number of lymph nodes metastases (x2 =11.423,HR =1.567,P =0.001 ),and MTV (x2 =3.872,HR =2.433,P =0.049 ) were significant predictors of survival.Multivariate analysis showed that MTV and AJCC stage were independent predictors of survival (x2 =4.525,HR1.170,P =0.033 ;X2=4.875,HR =3.071,P =0.027).Kaplan-Meier survival curves revealed longer survival time of low-MTV group as compared to high-MTV group ( Log-rank,x2 =4.186,P =0.041 ).ConclusionMTV on 18 F-FDG PET/CT may be an independent prognostic factor in patients with esophageal cancer.
