When should human papillomavirus (HPV) testing be done after conization?.
- Author:
So Young KIM
1
;
Eun Seop SONG
;
Suk Jin CHOI
;
Keun Sung KIM
;
Ki Eun LEE
;
Seok Mo KIM
;
Jee Hyung PARK
;
Sang Yong SONG
;
Yun Seob SONG
Author Information
1. Department of Obstetrics and Gynecology, Inha University, Incheon, Korea. songsong2000@hotmail.com
- Publication Type:Original Article
- Keywords:
LLETZ;
HPV oligonucleotide microarray;
HPV persistence
- MeSH:
Adenocarcinoma;
Conization*;
DNA;
Female;
Human Papillomavirus DNA Tests;
Humans*;
Oligonucleotide Array Sequence Analysis;
Pathology;
Seoul;
Uterine Cervical Neoplasms
- From:Korean Journal of Obstetrics and Gynecology
2006;49(7):1446-1454
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To know when human papillomavirus (HPV) testing should be done after conization. METHODS: Between 1997 to 2004, Large Loop Excisions of the Transformation Zone (LLETZ) were done for conization to women with cervical pathology at A University Hospital. The Pap and HPV typing were done before LLETZ procedures. After conizations, HPV typing were planned to be done every 3 months. Every HPV typing was done by HPV oligonucleotide microarray (Biomedlab Co., Seoul, South Korea). RESULTS: For 8 years, 120 LLETZ were enrolled in this study. There were 8 cases of no neoplasm, 9 cases of CIN 1, 17 cases of CIN 2, 74 cases of CIN 3, 10 cases of microinvasive cervix cancer, and 2 cases of adenocarcinoma in situ. HPV DNA before LLETZ procedures was found about 85.0% and subtype 16 was the most common type among the patients with cervical lesion (40.8%). After LLETZ, 190 HPV typing were done through 1,307 total months (average, 6.9 months/typing). 95 (79.2%) cases had negative results, and 25 (20.8%) cases had positive results. Our data showed that, after conization, about 80% turned out to negative in 6 months. CONCLUSION: Our data suggested HPV DNA testing should be done after 6 months of LLETZ, as about 80% were destined to negative in 6 months.
