The clinical significance of serum level of soluble intercellular adhesion molecule-1 detected before and after lung transplantation
10.3760/cma.j.issn.0253-9780.2010.05.018
- VernacularTitle:肺移植术前后血清可溶性细胞间黏附分子-1检测的临床意义
- Author:
Hua-long, XIAO
;
Guo-qiang, XIE
;
Guo-qian, CHEN
;
Xiao-feng, ZHANG
;
Xin-chen, QIANG
;
Jing-feng, YU
;
Lan, ZHU
;
Bing-fang, ZHU
;
Biao, HUANG
- Publication Type:Journal Article
- Keywords:
Lung transplatation;
Cell adhesion molecules;
Fluoroimmunoassay
- From:Chinese Journal of Nuclear Medicine
2010;30(5):343-345
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate serum soluble intercellular adhesion molecule-1 (sICAM-1) before and after lung transplantation for diagnosing acute rejection. Methods Biotin-streptavidin time resolved fluoroimmunoassay (BSA-TRFIA) was used to detect the concentration of serum sICAM-1 before and after lung transplantation in 26 patients. All patients were divided into stable lung transplantation group (n =16), acute rejection group (n =4) and infected group (n =6). The serum level of sICAM-1 in those groups was compared with that of the control group ( n = 30 ) by the non-parametric rank sum test ( KruskalWallis H test). Results No significant difference was found for serum sICAM-1 among the three groups and the control group before operation: (357.07 ± 220.01 ), ( 396. 18 ± 136.25 ), (468.95 ± 85.48 ) μg/L vs(348.63 ±69. 12) μg/L, H=6. 0436, P ＞0.05. However, when rejection and infection happened after operation, the serum sICAM-1 increased in the acute rejection group (455.53 ± 126.51 μg/L) and decreased in the infection group (146.43 ± 327.11 μg/L), and the level in the stable transplantation group was (274.23 ± 157.53 ) μg/L (H = 21. 8994, P ＜ 0.01 ). Conclusion Serum sICAM-1 level might be a potential marker to differentiate acute rejection from infection after lung transplantation.
