Evaluation of Tourette's syndrome by 99Tcm-TRODAT-1 SPECT imaging
10.3760/cma.j.issn.0253-9780.2011.02.008
- VernacularTitle:抽动秽语综合征的脑99Tcm-TRODAT-1SPECT显像
- Author:
Feng, DONG
;
Hong, LIU
;
Zhao-wei, MENG
;
Jian, TAN
;
Ben-shu, ZHANG
- Publication Type:Journal Article
- Keywords:
Tourette syndrome;
Brain;
Dopamine;
TRODAT-1;
Tomography,emission-computed,single-photon
- From:Chinese Journal of Nuclear Medicine
2011;31(2):104-107
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe dopamine transporter (DAT) binding capacity using 99Tcm-TRODAT-1 in drug-naive patients with Tourette's syndrome (TS) on SPECT imaging, and explore possible correlations between 99Tcm-TRODAT-1 uptake ratio and TS patient's age, disease duration, and tic severity.Methods Eighteen drug-naive TS patients, male 14, female 4, as well as 8 age- and gender-matched healthy subjects were recruited. Brain SPECT imaging was performed 2. 5 h after intravenous injection of 11.1 - 14.8 MBq/kg 99Tcm-TRODAT-1. ROI was drawn on the striatum including its sub-regions of caudate and putamen, with cerebellum as the background. Striatum/cerebellum ratio was calculated. Comparisons of the ratios between TS patients and controls were carried out by independent-sample t-test. Pearson correlation analysis was performed between DAT uptake ratios of striatum and patients' age, disease duration, tic severity. Results Compared with the control, higher symmetrically striatum uptake of 99Tcm-TRODAT-1 in TS patients was observed (2.17±0.23 vs 1.87±0.24, t =2.957, P＜0.05). Age (r= -0.320, P＞0.05)and tic severity(r = 0. 345, P ＞ 0.05) scores were not significantly correlated with specific uptake ratios measured in the striatum. But there was significant negative correlation between disease duration and the specific uptake ratios (r = - 0. 483, P ＜ 0. 05). Conclusions 99 Tcm-TRODAT-1 SPECT imaging may play an adjuvant role for initial evaluation of untreated TS.
