Relationship between the ende mic arsenism and the liver,renal damage
10.3760/cma.j.issn.1000-4955.2009.01.024
- VernacularTitle:地方性砷中毒与肝肾功能损伤关系研究
- Author:
Xiang, LI
;
Su-ping, WANG
;
Yong-liang, FENG
;
Hong, LUO
;
Ji-hua, ZHOU
;
Jian-wu, WANG
- Publication Type:Journal Article
- Keywords:
Arsenic poisoning;
Liver;
Kidney;
Acetylglucosaminidase
- From:Chinese Journal of Endemiology
2009;28(1):91-93
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the endemic arsenism and the liver,renal damage.Methods Some permanent residents were selected as investigated subjects who lived at 3 villages in Datong in Shanxi Province,an arseniasis-endemic areas,These objects were divided into arsenic poisoning and control group on the basis of Diagnosis Standard for Endemic Arsenism(WS/T 211-2001).Then blood and urine samples were collected in the surveyed people.Serum glutamate pyruvic transaminase(ALT)were detected by Enzyme-linked immunosorbent assay as the indicator of the impaired hepatic function.The microdosis albumen (mAlb)and acetylglucosaminidase(NAG)in urine were detected by end-point method and alkaline picric acid as the renal damage indicators.Results A total of 661 people investigated,of which 144 cases were arsenic poisoning patients.The rates of abnormal liver function were significant hisher in arsenic poisoning group[10.42% (15/144)]than that in control[5.22%(27/517)],and both wag significant[X2=5.107,P＜0.05;OR=2.11,95%CI (1.09-4.08)].The geometric mean of mAlb/Ucr was 2.16 mg/g Cr in control,and 2.31 mg/g Cr in arsenic poisoning group,and both was not significant(t=-1.71,P＞0.05).The geometric mean of NAG waft higher in arsenic poisoning group(2.43 U/g Cr)than that in the control(2.22 U/g Cr),and both was significant(t=-3.55, P＜0.05).Conclusions The damage of the liver and renal function were related with endemic arsenism,and NAG is the early indicators suggesting impaired renal function due to endemic arsenism.
