Research advance in the effect of potassium channel on pathogenesis of idiopathic optic neuritis
- VernacularTitle:钾离子通道在特发性视神经炎发病中的作用研究进展
- Author:
Jue, LIU
;
Pinghua, LI
- Publication Type:Journal Article
- Keywords:
idiopathic optic neuritis;
potassium channel;
potassium channel blockers
- From:Chinese Ophthalmic Research
2009;27(11):1054-1056
- CountryChina
- Language:Chinese
-
Abstract:
Idiopathic optic neuritis (ION) is a common disorder in neuro-ophthalmology. It harms vision function seriously. However, there are a lots of controversy and confusion about its etiology, etiopathogenesis and outcome of treatments. Recently, potassium channel, such as stichodactyla helianthus peptide (ShK) and TRAM-34, was found to be involved in the immunopathogenesis of ION, and regulation of potassium channel provide a novel immunomodulatory therapy for ION. This paper reviewed the research advance of potassium channel in ION. It is expected to further clarify the pathogenesis and search for effective treatment.
