Expression of cyclooxygenase-1 in ovarian cancer and its significance
- VernacularTitle:COX-1在卵巢癌组织中的表达及其意义
- Author:
Qiong, WU
;
Li-hong, BIAN
;
Chen-ming, HU
;
Ying, YANG
;
Yali, LI
- Publication Type:Journal Article
- Keywords:
cyclooxygenase-1;
ovarian cancer;
protein expression
- From:Bulletin of The Academy of Military Medical Sciences
2010;34(1):58-60
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of cyclooxygenase-1 in ovarian cancer and its significance. Methods Expression of COX-1 and CA125 was detected by immunohistochemistry in 37 cases of ovarian cancer and 31 cases of ovarian cyst. The serum level of COX-1 and CA125 was tested in 40 cases of ovarian cancer and 31 cases of ovarian cyst and 60 healthy volunteers by ELISA. Results The positive expression of COX-1 and CA125 was 78% and 57% in ovarian cancer and 3% and 7% in ovarian cyst,respectively. The expression of COX-1 and CA125 was 65% and 93% at the serum level. Conclusion Expression of COX-1 could act as an auxiliary diagnostic criterion in ovarian carcinoma.
