The effect of fluoride and arsenic pollution on bone metabolism in exposed population
10.3760/cma.j.issn.1000-4955.2011.04.011
- VernacularTitle:氟砷污染对暴露人群骨代谢的影响
- Author:
Qi-bing, ZENG
;
Yun, LIU
;
Ai-hua, ZHANG
;
Feng, HONG
;
Jun NG YA
;
Xian, YU
- Publication Type:Journal Article
- Keywords:
Fluorine;
Arsenic;
Enviromnental exposure;
Bones
- From:Chinese Journal of Endemiology
2011;30(4):393-395
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of fluoride and arsenic pollution on bone metabolism in exposed population. Methods One hundred and fifty-two fluoride and arsenic exposed people were selected from Jiaole village, Yuzhang town, Xingron county, Guizhou province in 2006, and 59 not exposed people from Daguoduo village 13 km away from Jiaole village were selected as control. Urinary fluorine(UF), urinary arsenic (UAs), urinary hydroxyproline (UHYP), cross-linked N-telopeptides of type I collagen (UNTX) and bone strength index(STI) were detected. Results The main effect of fluoride on UHYP and UNTX were statistically significant (F = 9.785, 4.225, P < 0.01 ), but was not significant on STI(F = 0.183, P > 0.05). The main effect of arsenic on UNTX was statistically significant (F = 2.660, P < 0.05 ), but was not significant on UHYP and STI(F = 2.012, 0.183,all P > 0.05). The interaction between fluoride and arsenic on UNTX was statistically significant (F= 2.429, P <0.01), but was not significant on UHYP and STI(F= 1.218, 1.001, all P> 0.05). Conclusions Fluoride exposure can affect the metabolism of collagen and bone resorption, and Arsenic exposure main affect bone resorption, fluoride and arsenic co-exposure have more significant effect on bone resorption. UNTX may be used as biological biomarker of bone metabolism for population co-exposed to fluoride and arsenic in health monitoring.