The effect of fluoride toxicity on free radical level in rats
- VernacularTitle:氟中毒对大鼠骨自由基含量的影响
- Author:
Xing-hua, LI
;
Bo, SUN
;
Guang-sheng, LI
- Publication Type:Journal Article
- From:Chinese Journal of Endemiology
2001;20(2):98-99
- CountryChina
- Language:Chinese
-
Abstract:
Objective Recently,it was reported the analy sis of bone free radical by using electron spin resonance (ESR),so this article aimed to determine the changes of bone free radical in fluoresis rats.Methods To analyze the free radical level of bone in fluoresis rats fed with different dose of calcium by ESR method.Results The free radical of bone in the group of low ca lcium level and the group low calcium+fluorides was higher than that in the cont rol group (P<0.01),but that in normal animal feeds (calcium-rich)+fluoride group was lower than that in the control group.Conclusions Low doses of fluoride did not resulted in the increase of free radical in calcium-rich condition at short time,but at low calcium condition,fluoride could increase the level of free radical,these suggested that simple overdose of fluoride did not change the level of free radical of bone.
