The regulation mechanism of RIG-Ⅰ-like receptors in antiviral innate immune responses
- VernacularTitle:抗病毒天然免疫反应中RIG-Ⅰ样受体调控机制新进展
- Author:
Dian-bo, LIU
;
Li, SUN
;
Bai-ling, ZHANG
;
Fei, YAN
;
Zhong-bin, CHEN
- Publication Type:Journal Article
- Keywords:
receptors,pattern recognition;
ubiquitination;
immunity,natural;
signal transduction
- From:Bulletin of The Academy of Military Medical Sciences
2010;34(1):84-88
- CountryChina
- Language:Chinese
-
Abstract:
Immune and tissue cells usually express pattern-recognition receptors (PRRs) to detect viruses and other microorganisms, thereby inducing signal cascade amplification and host innate immune responses. Since PRRs have strain-specific substrates and mechanisms of recognition, the identification of PRRs and mechanisms of PRRs-mediated responses is highly challenging. Besides, the research on RLRs-mediated immune responses has become more popular in cellular immunology recently. Accumulating evidence shows that post-translation modifications, such as ubiquitination, deubiquitination and ISGylation, play an important role in regulating host innate immune responses. In parallel, these approaches may be used by viruses to evade PRRs-mediated responses or to actively subvert these pathways for their own benefit. It was identified that STING (also called MITA/MPYS/ERIS) plays an important role in RIG-Ⅰ-like receptor(RLR) signaling as a type Ⅰ IFN stimulator, providing a special method for the research on complex host antiviral innate immune responses.
