The role of S100A4 in cancer cells and its potential application in the search for new treatment targets
- VernacularTitle:S100A4在癌细胞中的作用及其在寻找新治疗靶标中的应用
- Author:
Li-hui, LIU
;
Xiao-hua, CHEN
- Publication Type:Journal Article
- Keywords:
S100 proteins;
neoplasms;
neoplasm invasiveness;
antineoplastic agents;
treatment target;
cell cycle
- From:Bulletin of The Academy of Military Medical Sciences
2010;34(1):88-91
- CountryChina
- Language:Chinese
-
Abstract:
S100A4, a member of S100 superfamily of Ca~(2+)-binding proteins, is a polypeptide containing 101 amino acids. S100A4, which is overexpressed in most tumor cells, plays pivotal roles in growth, invasion and migration of tumor by regulating cell cycle progression, differentiation, apoptosis, invasion and metastasis of cells. This article reviews S100A4′s structure, function and potential application as the new target in the therapy of tumors.
