The labeling and animal study of tumor positive imaging agent 5-18F-fluorouracil
- VernacularTitle:肿瘤阳性显像剂5-18F-fluorouracil的标记与动物实验
- Author:
Zhibin, YUAN
;
Ruisen, ZHU
;
Katsumi TOMIYOSHI
;
Tomio, INOUE
;
Keigo, ENDO
- Publication Type:Journal Article
- From:Chinese Journal of Nuclear Medicine
2001;21(2):121-122
- CountryChina
- Language:Chinese
-
Abstract:
Objective To synthesize and label a tumor positive imaging agent 18F-fluorouracil (FU) and the animal study on the product was also undertaken. Methods 18F-FU was synthesized and labeled. Its biodistribution analysis was done on normal and tumor bearing nude mice. PET imaging was performed on normal and tumor bearing rabbits. Results HPLC analysis and other quality control test results guaranteed the possibility of animal study and clinical usage of 18F-FU. Biodistribution analysis and PET imaging also demonstrated a high accumulation of the tracer in tumor tissue. Conclusion 18F-FU is a kind of potential tumor positive imaging agents which can be used to assess the effects of chemotherapy.
