Enlightenment from corneal wound healing for excimer laser refractive surgery
- VernacularTitle:角膜伤口愈合机制对准分子激光角膜屈光手术的启示
- Author:
Yifeng, QIAN
;
Jinhui, DAI
- Publication Type:Journal Article
- Keywords:
corneal wound healing;
epithelial cells;
basement membrane;
refractive surgery;
haze
- From:Chinese Ophthalmic Research
2009;27(12):1146-1149
- CountryChina
- Language:Chinese
-
Abstract:
Wound healing in the human cornea has distinctive characteristics in comparison to most other tissues in the body.The corneal wound healing response is a remarkably complex cascade mediated by cytokines,growth factors,and chemokines.The interactions in the epithelial,stromal,neural,lacrimal gland,immune cells are interwoven in the corneal response to injury.Corneal epithelial cells and basement membrane play important roles in this process.However,both of them are usually impaired during the procedures of excimer laser refractive surgery for myopia,hyperopia,or astigmatism,and complications such as overcorrection,undercorrection,regression,refractive instability,and haze may occur after surgery.A complete corneal wound healing process,the biologic and molecular processes that contribute to the healing response,and anomalies that lead to complications are critical for improving the efficacy and safety of excimer laser refractive surgical procedures.
