The advanced genomics research of neurofibromatosis type 1
10.3969/j.issn.1003-0808.2010.02.023
- VernacularTitle:1型神经纤维瘤病的基因学研究进展
- Author:
Ke, YIFENG
;
Hao, RUI
;
Zhang, HONG
- Publication Type:Journal Article
- Keywords:
neurofibromatosis type 1;
neurofibromatosis gene;
genetics;
genomics;
gene mutation
- From:Chinese Ophthalmic Research
2010;28(2):184-187
- CountryChina
- Language:Chinese
-
Abstract:
Neurofibromatosis type 1 is a term of Von Recklinghausenan.It is an autosomal dominant inherited disease which derived by neural crest cell.Prevalence of this disease is 1/3000 1/3500 and is a disease with the highest mutation rate.The pathogenesis of neurofibromatosis type 1 is associated with the deficiency of NF1 gene.Recently,the genetics and genomics research of neurofibromatosis make a great progress.With the development of gene linkage and position cloning technology,the gene sequence of neurofibromatosis type 1 has been found.Recent research of genetics and genomics of NF1 and the structure and function,abnormal expression,the relation of genotype and phenotype,the mutation sensitivity domain of NF1 gene were reviewed.
