Renal function reserve in patients with early type 2 diabetic nephropathy using protein loading-scintirenography
10.3760/cma.j.issn.0253-9780.2010.03.012
- VernacularTitle:蛋白质负荷肾显像观察2型糖尿病早期肾病的肾储备功能
- Author:
Rong-rong, TIAN
;
Cheng-gang, ZHANG
;
Hao, QI
;
Xian-feng, LI
;
Jin, WANG
;
Jian-zhong, LIU
;
Si-jin, LI
;
Fei, GAO
;
Jing, YANG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,non-insulin-dependent;
Diabetic nephropathies;
Radionuclide imaging;
DTPA
- From:Chinese Journal of Nuclear Medicine
2010;30(3):185-188
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore a sensitive method and index to evaluate renal functional reserve (RFR) in patients with early diabetic nephropathy (DN) using protein loading-scintirenography.Methods Fifty subjects were studied and divided into 3 groups.Group one (G1) consisted of 14 healthy volunteers;Group two (G2) consisted of 15 patients with type 2 diabetes mellitus (DM) and normoalbuminuria; Group three (G3) consisted of 21 patients with type 2 DM and microalbuminuria.All subjects underwent baseline and protein loading-99 Tcm-DTPA scintirenography within one week.RFR was calculated as the difference between stimulated and baseline glomerular filtration rate (GFR), time of peak ( Tb ), time of half excretion ( C1/2 ), residual rate at 20 min ( C20/b ) .Variance analysis and t-test were used to analyze the group differences.Results ( 1 ) The RFR in terms of GFR had statistical difference between any two groups (t=14.884, 32.180, 16.042, all P＜0.01).After protein-loading, the GFR of G1, G2 and G3 increased 20.1, 10.9 and 2.2 ml·min-1·1.73 m-2 respectively.Therefore, the RFR decreased before microalbuminuria in type 2 DM patients.(2)There was statistical difference between the RFR of G1 and G2 in terms of C1/2 (t = 5.505, P＜0.05 ), and between G1 and G3 ( t = 8.914, P＜0.01 ).(3) There was statistical difference of the RFR in terms of TP between G1 and G3 (t = 5.690, P ＜ 0.01 ).(4) There was statistical difference of the RFR in terms of C20/b between G1 and G3 (t= 4.376, P＜0.05 ).Conclusions 99Tcm-DTPA protein loading-scintirenography is an effective method for measuring RFR to evaluate early DN in type 2 DM patients.
