Detecting underlying malignancy with 18F-FDG PET/CT in patients with suspected paraneoplastic neurological syndrome

VernacularTitle:18F-FDG PET/CT在可疑神经系统副肿瘤综合征中的应用价值
Author: Yuan-yuan, GENG ; Shuo, GAO ; Bing-di, XIE ; Qiu-song, CHEN ; Li, CAI ; Yan-qing, LIU
Publication Type:Journal Article
Keywords: Paraneoplastic syndromes,nervous system; Tomography,emission-computed; Tomography,X-ray computed; Deoxyglucose
From:Chinese Journal of Nuclear Medicine 2010;30(3):163-165
CountryChina
Language:Chinese
Abstract: Objective To evaluate 18F-fluorodeoxyglucose (FDG) PET/CT in detecting occult malignancy in patients with suspected paraneoplastic neurological syndrome (PNS).Methods Twenty consecutive patients who underwent PET/CT scanning with the indication of suspected PNS were retrospectively reviewed.The gold standard of PNS was either cytology or clinical follow-up, and the final diagnosis was compared with PET/CT findings.Results Of the 20 patients, six were PNS.PET/CT detected nine cases.Six were true positive and three were false positive.The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of PET/CT were 100% (6/6), 78.57% (11/14), 85.00% (17/20),66.7% (6/9) and 100.00% ( 11/11 ) respectively.The treatment plan was modified based on the PET/CT results in 4 patients.Conclusions 18F-FDG PET/CT may play a role in detecting the underlying malignancy of PNS.It is also valuable in staging of the malignancy thus providing information for therapy decision making.