Comparison of glomerular filtration rates by dynamic renal scintigraphy and dual-plasma sample clearance method in diabetic nephropathy

VernacularTitle:肾动态显像法与双血浆法测定糖尿病肾病患者GFR的比较
Author: Peng, XIE ; Jian-min, HUANG ; Li-ping, PAN ; Xiao-mei, LIU ; Ling-ge, WEI ; Jian-qing, GAO
Publication Type:Journal Article
Keywords: Diabetic nephropathies; Glomerular filtration rate; Radionuclide imaging; DTPA
From:Chinese Journal of Nuclear Medicine 2010;30(4):276-278
CountryChina
Language:Chinese
Abstract: Objective To evaluate the accuracy of renal scintigraphy for the estimation of glomerular filtration rates (dGFR) in patients with diabetic nephropathy as compared to the conventional dual-plasma sample clearance method (pscGFR). Methods Forty-six patients with diabetic nephropathy underwent both dynamic renal scintigraphy and dual-plasma sample measurement after 99Tcm-DTPA injection. Paired student t-test and correlation analysis were performed to compare dGFR and pscGFR (normalized to body surface area,1.73 m-2). Results The mean dGFR was higher than mean pscGFR ((51.08±26.78)ml·min-1vs (44.06±29.43)ml·min-1,t=4.209,P=0.000). The dGFR correlated with pscGFR ( r=0.923,P=0.000) linearly (regression equation:pscGFR=1.015×dGFR-7.773,F=254. 656,P=0.000).Conclusions dGFR correlated well with pscGFR. Although it could not absolutely replace the latter in patients with diabetic nephropathy,dGFR could reasonably evaluate the filtration function for these patients.