Comparison of Alzheimer's disease animal model in BALB/c and Kunming mice by intracerebroventricular injection of β-amyloid
- VernacularTitle:BALB/c和昆明小鼠Aβ侧脑室注射建立阿尔茨海默病小鼠模型比较
- Author:
Gang, LIU
;
Zeng-Yao, HU
;
Sheng, YANG
;
Wen-Xia, ZHOU
;
Yong-Xiang, ZHANG
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
animal model;
intracerebroventricular injection;
β-amyloid
- From:Bulletin of The Academy of Military Medical Sciences
2009;33(6):554-557
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the Alzheimer's disease model in two species of mice by intracerebroventricular injection of β-amyloid peptide 25-35(Aβ_(25～35)).Method:The step down test and Morris water-maze were used to investigate the influence of the mice's learning and memorizing ability after intracerebroventricular injection of β-amyloid.Results:Normal Kunming mice and BALB/c mice had no significant difference in step down test, but the space cognitive ability of Kunming mice was better than that of BALB/c mice. The learning response in step-down test and Morris water-maze is no influence in male, female BALB/c mice and female Kunming mice. Marked differences were observed in male Kunming mice in acquisition, performance and reversal of a place learning response in a Morris water-maze.Conclusion:The male Kunming mice is much better than female Kunming mice and male, female BALB/c mice in preparing Alzheimer's disease animal model by intracerebroventricular injection of Aβ_(25～35), and is the most suitable animal in this experiment.
