Observation on cerebral artery kinetics in patients with chronic Keshan disease
- VernacularTitle:慢型克山病患者脑血流动力学观察
- Author:
Yan-li, ZHANG
- Publication Type:Journal Article
- Keywords:
Keshan disease;
Ultrasonography,doppler,transcranial;
Cerebrovascular circulation;
Kinetics
- From:Chinese Journal of Endemiology
2008;27(4):449-451
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe changes of eerebral blood flow kinetics in chronic Keshan disease patients to facilitate the clinical diagnosis and treatment. Methods The patients were divided into two groups according to the X-ray examination: 39 patients with a moderately enlarged heart in a eardiothoraeic ratio of 0.55～ 0.60 and 47 patients with a markedly enlarged heart in a cardiothoraeic ratio 0.60. Another group of 35 healthy individuals was included as controls. Cerebral arteries mean velocity (Vm), pulsatility index (PI), and resistance index(RI) of middle cerebral artery(MCA), anterior cerebral artery(ACA), posterior cerebral artery(PCA), basilar artery(BA), and vertebral artery(VA) were determined with transcranial Doppler(TCD) to observe. Results ①Vm of MCA being(57.4±8.9), (55.1±7.9)cm/s, ACA being(41.6±8.5), (39.5±8.1)cm/s, VA being(35.6±7.8), (33.5±7.6)em/s in the groups of individuals with a moderately or markedly enlarged heart were significantly decreased eompared with those of the control group, the latter being(63.2±11.6),(47.3±10.9),(39.7±9.5) era/s, with statical signifieances(P<0.05). PCA[(31.2±8.3)cm/s], BA[(38.7±7.9)cm/s] in the group of markedly enlarged heart also significantly were decreased, compared with those of the control group[ (38.1±10.5), (45.3±11.7)cm/s] ,and the difference being statically signifieant(P<0.05). ②As for PI, MCA(0.92±0.12, 1.01±0.13), ACA(0.90±0.14,0.94±0.15), PEA(0.89±0.15,0.92±0.14), BA(0.93±0.13,0.96±0.15), VA(0.91±0.14, 0.93±0.16) in the groups of individuals with a moderately or markedly enlarged heart significantly were increased, respectively compared with those of the control group(0.74±0.10,0.77±0.15,0.72±0.13,0.68± 0.12,0.69±0.14) with statical significances(P<0.05). Moreover, the increase was more pronounced in the markedly enlarged heart group than the moderately enlarged group(P<0.05). ③RI with ACA(0.63±0.06,0.70± 0.07), PCA(0.62±0.07,0.65±0.08), BA(0.66±0.09,0.68±0.10) and VA(0.63±0.08,0.64±0.09) in the groups with a moderately or markedly enlarged heart were significantly increased, compared with those of the control group(0.52±0.07,0.54±0.08,0.56±0.07,0.57±0.06) respectively with statical significances(P<0.05). Moreover, the increase was more pronounced in the heart markedly enlarged group than in the moderately enlarged heart group(P<0.05). MCA(0.67±0.09) in the groups of individuals with a markedly enlarged heart significantly increased, compared with those of the control group(0.53±0.06) and in the groups of individuals with a moderately enlarged heart(0.65±0.07), the difference had statical significances(P<0.05). Conclusions The chronic Keshan disease patients exhibits cerebral blood flow kinetic changes. In some serious cases, the cerebral blood flow changes more obviously. TCD has proven to be a simple, accurate and reliable method to detect cerebral blood flow kinetics changes in chronic Keshan disease patients, thus can be a help in the diagnosis and treatment of chronic Keshan disease.
