Pulmonary perfusion imaging combined with Wells score and D-dimer assay for the diagnosis of acute pulmonary embolism
10.3760/cma.j.issn.0253-9780.2011.01.011
- VernacularTitle:肺灌注显像结合Wells评分及D-二聚体检查对急性肺血栓栓塞症的诊断价值
- Author:
Chen, LIU
;
Wei, FANG
;
Feng, WANG
;
Chang-ming, XIONG
;
Zhi-hui, ZHAO
;
Qing, GU
;
Zuo-xiang, HE
- Publication Type:Journal Article
- Keywords:
Pulmonary embolism;
Thromboembolism;
Radionuclide imaging;
Tomography,X-ray computed;
Fibrin fibrinogen degradation products;
MAA
- From:Chinese Journal of Nuclear Medicine
2011;31(1):42-45
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of the Wells score and D-dimer assay in assisting pulmonary perfusion imaging (PPI) for the diagnosis of acute pulmonary embolism (APE). Methods One hundred twenty-one patients with suspected APE were studied from January, 2006 to December, 2008. All patients underwent the Wells score, the quantitative D-dimer assay, chest X-ray photography, and PPI. The diagnostic sensitivity, specificity, positive predictive value and negative predictive value of PPI with the assistance of Wells score and D-dimer assay were calculated. Results Fifty (41.3%) patients were diagnosed with APE. PPI combined with chest X-ray photography (Q/X scan) showed positive results in 49 patients. The sensitivity, specificity, positive predictive value and negative predictive value of the Q/X scan were 86.0% (43/50), 91.5% (65/71), 87.8% (43/49) and 90.3% (65/72), respectively. With assistance of Wells score >4 and D-dimer≥0. 5 mg/L, Q/X scan had a positive predictive value of 100.0% (29/29), for patients with Wells score ≤4 and D-dimer<0.5 mg/L, the negative predictive value for Q/X scan was 100.0% (41/41). Conclusion Combined with Wells score and D-dimer assay, PPI can make accurate diagnosis of APE.
